RC4 - Roller Coaster 4 - Birds of a Feather 5

Wednesday, November 13, 2024

10:45 AM – 12:15 PM MST

Location: Kaibab & Lantana

Moderator(s)

Annie Lumen, PhD

Senior Principal Scientist
Clinical Pharmacology Modeling & Simulation, Amgen
Blue Bell, Pennsylvania, United States

Speaker(s)

XZ

Xinwen Zhang, PhD

Principal Scientist
Clinical Pharmacology Modeling & Simulation, Amgen, United States
VH

Vincent Hurez, DVM, PhD (he/him/his)

Director Group Quantitative Pharmacology
Regeneron Pharmaceuticals Inc.
Tarrytown, New York, United States
John Panetta, PhD (he/him/his)

Biomedical Modeler
St Jude Children's Research Hospital
Memphis, Tennessee, United States
Wilhelmus De Witte, PhD

Lead Large Molecule Platform - Principal Scientist
ESQlabs, Belgium
Zackary Kenz, PhD

Principal Scientist
Simulations Plus, United States

PDF Slides

Disclosure(s):

Annie Lumen, PhD: No financial relationships to disclose

Xinwen Zhang, PhD: Amgen: Employment (Ongoing), Ownership Interest (stocks, stock options, patent or other intellectual property or other ownership interest excluding diversified mutual funds) (Ongoing)

Vincent Hurez, DVM, PhD: Regeneron Pharmaceuticals, Inc.: Employment (Ongoing), Ownership Interest (stocks, stock options, patent or other intellectual property or other ownership interest excluding diversified mutual funds) (Ongoing)

John C. Panetta, PhD: No financial relationships to disclose

Wilhelmus E.A. De Witte, PhD: No financial relationships to disclose

Zackary R. Kenz, PhD: Simulations Plus: Employment (Ongoing), Ownership Interest (stocks, stock options, patent or other intellectual property or other ownership interest excluding diversified mutual funds) (Ongoing)

Presentations:

10:50 AM – 11:05 AM MST

Mechanistic physiologically-based pharmacokinetic models for optimal development of bi-specific T cell engagers
Speaker: Xinwen Zhang, PhD – Clinical Pharmacology Modeling & Simulation, Amgen
11:05 AM – 11:20 AM MST

A mechanistic model to inform step-up dosing that limits cytokine release following a bispecific T cell engaging antibody treatment for B-cell lymphomas
Speaker: Vincent Hurez, DVM, PhD (he/him/his) – Regeneron Pharmaceuticals Inc.
11:20 AM – 11:35 AM MST

Fludarabine Therapeutic Drug Monitoring in Lymphodepletion Therapy for Pediatric CAR T-cell therapy
Speaker: John C. Panetta, PhD (he/him/his) – St Jude Children's Research Hospital
11:35 AM – 11:50 AM MST

The Future of Pharmacokinetics: Digital Twins and OoC in Harmony
Speaker: Wilhelmus E.A. De Witte, PhD – ESQlabs
11:50 AM – 12:05 PM MST

Weight Loss and Nausea from Subcutaneous and Oral Semaglutide Accurately Simulated with a QSP Model
Speaker: Zackary R. Kenz, PhD – Simulations Plus