BOAF4 - Opening New Frontiers in Pharmacometrics & QSP Modeling: Leveraging Physics- and Pharmacology-informed Neural Networks

Wednesday, November 13, 2024

9:00 AM – 10:30 AM MST

Location: Kaibab & Lantana

Chair and Speaker(s)

James Lu, PhD (he/him/his)

Distinguished AI Scientist
Clinical Pharmacology, Genentech Inc., California, United States

Nazanin Ahmadi Daryakenari, PhD Candidate (she/her/hers)

Research Assistant
Biomedical Engineering, Brown University
Providence, Rhode Island, United States
Damilola Olabode, PhD (she/her/hers)

Associate Director
Quantitative Clinical Pharmacology, AstraZeneca
Wilmington, Massachusetts, United States

Disclosure(s):

James Lu, PhD: Genentech, Inc.: Employment (Ongoing)

Diansong Zhou, PhD: No financial relationships to disclose

Nazanin Ahmadi, MS: No financial relationships to disclose

Damilola O. Olabode, PhD: AstraZeneca: Employment (Ongoing); Sail Biomedicine: Employment (Ongoing)

9:00 AM – 9:30 AM MST

Merging Multimodal with Longitudinal data: Leveraging Graph Neural Networks and Neural-ODEs
Speaker: James Lu, PhD (he/him/his) – Clinical Pharmacology, Genentech Inc.
9:30 AM – 10:00 AM MST

Pharmacometrics Modeling via Physics-Informed Neural Networks: Integrating Time-Variant Absorption Rates and Fractional Calculus for Enhancing Prediction Accuracy
Speaker: Nazanin Ahmadi Daryakenari, PhD Candidate (she/her/hers) – Biomedical Engineering, Brown University
10:00 AM – 10:30 AM MST

Machine Learning for Developing Interpretable Population PK Models
Speaker: Damilola O. Olabode, PhD (she/her/hers) – Quantitative Clinical Pharmacology, AstraZeneca