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Lang Li, PhD

Professor and Chair
Department of Biomedical Informatics, College of Medicine, The Ohio State University
Columbus, Ohio, United States

Dr. Lang Li is a Professor and Chair in the Department of Biomedical Informatics in the College of Medicine at the Ohio State University. He has developed and specialized on the translational pharmacology research in drug interaction and cancer systems biology. Using systems bioloy models, statistical methods, ML/AI algorithms and informatics approaches, Dr. Li’s lab translates molecular mechanisms of drug interactions and pharmacogenetics into pharmaco-epidemiology studies, and vice versa. Dr. Li successfully identified loratadine/simvastatin interaction induced myopathy in mining both PubMed literature and electronic medical records. Further in vitro studies demonstrated that loratadine/simvastatin interaction induced myopathy is likely due to the direct muscle myocyte toxicity. Recently, using large language models and literature based text mining, Dr. Li and his lab develop a number of knowledge bases and tools for clinical and translational research in phase I cancer clinical trial design (DrugCombo), pharmacotherapy knowledge gap discovery in pediatric and maternal (MPRINT-KP) patient populations, and synethtic lethal gene pair discovery (SLKB) in cancer research. Dr. Li’s research has been continuously funded by NLM, NIGMS, NCI, NICHD, and NCATS for over 20 years.

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