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Jeffrey West, PhD

Assistant Member
H. Lee Moffitt Cancer Center & Research Institute

Jeffrey West, PhD, is an Assistant Member in the Department of Integrated Mathematical Oncology at Moffitt Cancer Center. His training is in applied mathematics with a focus in dynamical systems, game theory, control theory, and computational methods. The goal of his research program is to aid in targeting treatment resistance by constructing mathematical models of 1) tumor evolution and heterogeneity and 2) evolutionary-minded treatment strategies, employing techniques such as agent-based modeling, dose response convexity analysis and evolutionary game theory. Recent publications use mathematics to design and guide evolution-based treatment strategies, with a focus on metastatic castration-resistant prostate cancer. He recently helped lead an effort for a multi-institutional perspective paper on the process of bridging mathematics to clinical translation (published in eLife). Ongoing research in his group aims to contribute to the goal of designing evolutionary-minded and ecological treatment strategies in various settings. For example, another recently published collaborative paper focused on the clinical translation of evolutionary-minded treatment strategies across cancer types (Annals of Oncology). Finally, previous work in agent-based modeling includes the development of open-source software, Hybrid Automata Library, to perform simulations, and a recent review paper describing the process for translating biological knowledge into the design process for constructing the ruleset underlying agent-based models (Trends in Cell Biology). Read more at: https://labpages.moffitt.org/westj/.

Disclosure(s): No financial relationships to disclose

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