Associate Principal Scientist Certara Sheffield, United Kingdom
Disclosure(s): No financial relationships to disclose
Disclosure(s):
Felix Stader, PhD: No financial relationships to disclose
This year, Certara UK is running a one-day Simcyp hands-on workshop on developing population-PBPK driven PD/QSP (quantitative systems pharmacology) models within its new integrated platform "Simcyp Designer". The course reviews the fundamentals of PBPK and QSP modelling using the Simcyp Simulator and builds rapidly to specialised applications where you will modify existing PBPK models with your own PD/QSP extensions. We will also examine the propagation of population variability to mechanistic models of therapeutic effects dynamically interacting with drug distribution models, as well as analysing population variability in clinical data.
The key topics covered are: •Latest advances of PBPK modelling using the Simcyp Simulator, •Generation of realistic population variability using correlated Monte Carlo sampling, covariate modeling withing the Simcyp Simulator, •Replacing or modifying a tissular compartment within the Simcyp Simulator with a user-defined model, •Creating PD/QSP models using the Simcyp Designer's graphical editor, •Incorporating physiological covariates within a user-defined mechanistic effect model, •Adding target mediated drug disposition (TMDD) processes to tissue compartments, •Extending PBPK models for therapeutic proteins, •Optimising PBPK models using data across different clinical trials simultaneoulsy.
