PHARM002 - (R)TTE analysis: MIDD applications, concept, methodology and NONMEM hands-on, Pharmetheus

Objective of this workshop is to enhance attendees’ knowledge of time to event (TTE) and repeated TTE (RTTE) modeling in NONMEM, both in theory and practice. Target audience is students and/or pharmacometricians with no or limited experience with TTE/RTTE modeling.
Workshop Provides:
Day 1:
*Motivation for running survival analyses from a model-informed drug development perspective, with key speakers from academia and industry.
Day 2
*Introduction to general concepts and theory, typical TTE/RTTE analysis followed by data formatting and key aspects of graphical exploration of TTE/RTTE data.
*Detailed Insights to NONMEM code useful for the model development, such as standard and alternative function parameterization, implementation of exposure-response relationships and estimation of covariate effects.
*Overview of efficient simulation frameworks will be presented, with a focus on NONMEM coding and derived metrics to graphically communicate on. *Several hands-on sessions to help the attendees appreciate the specificities of TTE/RTTE models in terms of evaluation and diagnostics.

After the workshop the attendees will be able to understand, conduct and communicate TTE and RTTE modeling analyses.
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