Mathematical and Computational Sciences Special Interest Group of International Society of Pharmacometrics will present a one-day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using Phoenix. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) and distributed delay differential equations (DDDEs) will be introduced and implemented in Phoenix. The course will consist of both lectures and hands-on computer exercises. Source codes for DDE and DDDE based PK/PD models and data will be provided to the participants.
Learning Objectives:
Learn biology and pharmacology underlying delays in PK/PD systems
Introduce mathematical and computational basics of DDEs and DDDEs
Gain hands-on experience with implementing PK/PD models in Phoenix
